Keep an eye on Closely (1)pentobarbital will minimize the level or outcome of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to the decrease in fentanyl plasma concentrations, not enough efficacy or, probably, improvement of a withdrawal syndrome in a affected person who has created physical dependence to fentanyl. Following stopping a CYP3A4 inducer, as the effects of your inducer decline, the fentanyl plasma focus will improve which could raise or lengthen the two the therapeutic and adverse effects.
pentobarbital will reduce the extent or impact of docetaxel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.
pentobarbital will reduce the extent or outcome of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will minimize the level or outcome of propafenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
pentobarbital will decrease the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital increases toxicity of buprenorphine, extended-performing injection by pharmacodynamic synergism. Modify Therapy/Observe Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants improves possibility of adverse reactions like overdose, respiratory despair, and Dying. Cessation of benzodiazepines or other CNS depressants is most well-liked in most cases.
pentobarbital boosts toxicity of methoxyflurane by rising metabolism. Contraindicated. Enhanced metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will minimize the extent or impact of etravirine by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep track of.
pentobarbital will improve here the stage or result of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers decreased ivosidenib plasma concentrations.
pentobarbital will minimize the level or impact of trazodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Contraindicated (1)pentobarbital will decrease the extent or outcome of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or impact of flurbiprofen by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Importance Mysterious.
pentobarbital will minimize the level or influence of etonogestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the extent or impact of siponimod by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of siponimod which has a drug that causes reasonable CYP2C9 moreover a moderate or sturdy CYP3A4 inducer isn't encouraged.